Learning Notebook - David Rostcheck
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Dr. Levin discusses the relationship between AI and biomedicine, emphasizing the importance of understanding the natural intelligence of the body to advance regenerative medicine. He introduces the concept of non-neural bioelectricity as a software layer of physiology and a new kind of epigenetics, which could enable a class of electroceuticals in heart defects, regenerative medicine, cancer, and synthetic biology. Dr. Levin also envisions a future where individuals can draw the anatomical layout of an organ or appendage they desire, and software, referred to as an anatomical compiler, would convert this description into a set of stimuli to build the desired shape. He emphasizes the importance of understanding how cells work together to build complex structures and the role of bioelectricity in achieving large-scale goals. Dr. Levin's research focuses on using AI and machine learning to identify electrical patterns associated with organ development and manipulating these patterns to induce specific cell behaviors and organ development. He also discusses the potential of using machine learning models to identify specific ion channels that can be manipulated to recover complex defects in the brain. Throughout the video, Dr. Levin acknowledges the contributions of students, funders, and model systems to his research and engages with audience questions. Dr. Levin explores the use of machine learning in understanding the regulatory circuits within cells and predicting new experiments. He discusses how they used an evolutionary algorithm to create a model of planarian regulatory circuits and the potential of using machine learning to infer patterns in large bioelectric measurement data. Dr. Levin also explains the concept of electroceuticals, emphasizing that electrical patterns in an organism's hardware shape its features, not just its genetics. He mentions the challenges of setting up stable, steady long-term distributions of electrical potentials in cells using electrodes and the limitations of using electrical fields for the complex patterns required for electroceuticals. Dr. Levin uses physics concepts such as symmetry breaking and self-organization to explain the origin of electrical patterns in tissue and the role of evolution in optimizing electrical ion channels for useful organism
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